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Brand :Lansopharm15, 30
Generic Name:Lansoprazole 15, 30
Pharmacological Classification: Gastric acid pump inhibitor, antiulcer agent.
Effect Mechanism:

Lansoprazole is a selective and irreversible proton pump inhibitor.

Indications :

Gastroesophageal reflux disease (GERD) (prophylaxis and treatment)

• Ulcer, gastric treatment

• Ulcer, duodenal (prophylaxis and treatment)

• Ulcer, duodenal, Helicobacter pylori - associated (treatment)

• Hypersecretory conditions, gastric (treatment)

Consumption during pregnancy and lactation:

• FDA Pregnancy Category B.

. It is not known whether lansoprazole is distributed into breast milk.

Common side effects :

Those indicating need for medical attention:

Incidence more frequent

Diarrhea, skin rash or itching.

Incidence less frequent

Abdominal or stomach pain; arthralgla (jolnt paln}; Increased or decreased appetre; nausea, vomidng.

• Incidence rare:

Anxiety, constipation; influenza - like syndrome; increased cough mental depression myalgia; thrombocytopenia; ulcerative colitis, upper respiratory tract inflammation or infection.

2- Those indicating need for medical attention only if they continue or are bothersome:

• Incidence more frequent

Diziness, headache.

• Incidence less frequent

Constipation; nausea.

Common side effects of drug interactions:


• Lansoprazole, by increasing gastric pH, has the potential to affect the bioavailability of any medication whose absorption is PH dependent.

 Also, lansoprazole may prevent the degradation of acid labile drugs.

Possible interactions of lansoprazole with medications known to be metabolized by the hepatic cytochrome P450 enzyme

system should be considered.

• Combinations containing any of the following medications depending on the amount present may also interact with this medlcadon:

- Ampicillin esters, digoxin, Iron salts and ketoconazole (lansoprazole causes prolonged inhibition of gastric acid secretion, and thereby may interfere with the absorption of those medications and others for which bloavallabiilty is determined by gastric pH).

- Cyanocobalamin: lansoprazole appears to produce a dose-dependent decrease in the absorption of cyanocobalamin.

- Sucralfate: lansoprazole absorbtion is delayed and bioavailability is decreased; lansoprazole should be taken at least 30 minutes prior to sucralfate.

Warfrain concomitout use may increase INR. 

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