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Cream
Brand :Clobetasol Medipharm 0.05
Generic Name:Clobetasol propionate
Pharmacological Classification: • Corticosteroid (topical)
Effect Mechanism:

• Corticosteroids diffuse across cell membranes and complex with sepecific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin) ,and stimulate transcription of mRNA and subsequent protein synthesis of various inhibitory enzymes responsible for the anti inflamatory effects of topical corticosteroids.


Indications :

• Dermatitis, atopic, mild to moderate 

• Dermatitis, contact 

Dermatoses, inflammatory and other form of 

• Eczema 

Sunburn . Psoriasis 

Lichen Planus 

• Lupus erythematosus 

• Alopecia areata 

• Dermatitis, seborreic

Consumption during pregnancy and lactation:

• FDA Pregnancy Category C.

. It is not known whether topical corticosteroids are distributed into breast milk. 

• Tell your doctor if you are pregnant or breast feeding.

Common side effects :

 Systemic side effects:

 Hyperglycemia, glycosuria and HPA axis suppression, cushing's syndrome. 

• Local side effects: 

Allergic contact dermatitis ( burning, itching, redness, stinging and thinning of the skin ), acne, pustules, 

purpura , changes in skin pigmentation, infection.  

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