Diclofenac Sodium Medipharm Tablets | Sustained Release

Description

Diclofenac sodium sustained-release tablets are one of the advanced pharmaceutical forms in the nonsteroidal anti-inflammatory drugs (NSAIDs) class. These tablets are designed with a special structure that allows for the gradual release of the active ingredient over several hours. This reduces the need for frequent administration and maintains therapeutic efficacy throughout the day. This pharmaceutical form has found a special place, especially in the management of chronic pain, reducing joint inflammation and relieving muscle discomfort.

Pharmaceutical composition and pharmacological properties

Diclofenac sodium is a member of the phenylacetic acid derivative family and exerts its action by inhibiting the cyclooxygenase (COX) enzyme. This enzyme is responsible for the production of prostaglandins, which play a central role in inflammatory processes, pain, and fever. Inhibition of COX directly reduces inflammatory symptoms and pain.

Sustained-release formulations, using special polymers and absorption-controlling matrices, provide a uniform release of the drug in the gastrointestinal tract. The bioavailability of the drug in this form, although slightly slower than the immediate-release form, has a more sustained and reliable efficacy. The half-life of diclofenac is usually between 1 and 2 hours, but with a sustained-release design, the therapeutic effect can last up to 12 hours.

Therapeutic uses of Diclofenac Sodium Medipharm tablets

Diclofenac sodium extended-release tablets are used to treat a wide range of painful and inflammatory conditions. Common cases include muscle pain, back pain, tension headaches, and post-surgical pain. This medication is also very effective in treating joint inflammation such as osteoarthritis and rheumatoid arthritis.

In patients with ankylosing spondylitis, which is characterized by stiffness and inflammation of the spine, regular use of diclofenac significantly improves quality of life. The anti-inflammatory properties of this drug make it an effective option in relieving pain caused by chronic inflammation, especially when combined with physiotherapy and other treatments.

The correct method of use and important dosage tips for Medipharm Diclofenac Sodium tablets

Proper medication administration is essential for optimal therapeutic results. Diclofenac sodium extended-release tablets should be swallowed whole with a sufficient amount of water, without crushing or chewing. It is best to take the medication after a meal to reduce the risk of stomach irritation.

The usual adult dose is 75 to 150 mg per day, which may be given in a single or divided dose. 30-count packs are used for shorter courses or initial prescription by a physician. Patients should avoid taking diclofenac with other NSAIDs, such as ibuprofen or naproxen, unless directed by a physician, as this combination may increase the risk of gastrointestinal side effects.

Side effects, drug interactions, and precautions for Medipharm Diclofenac Sodium tablets

Diclofenac sodium tablets may cause side effects, especially in high doses or over a long period of time. The most common side effects include stomach pain, indigestion, nausea, and in some cases, peptic ulcers. In rarer cases, there is also a risk of cardiovascular complications such as increased blood pressure or worsening of heart disease. Drug interactions with anticoagulants (such as warfarin), diuretics, and some ACE inhibitors should also be carefully considered. Concomitant use with alcohol or smoking doubles the risk of gastrointestinal damage.

Before starting the use of diclofenac sodium extended-release, the patient's history of kidney, liver, digestive and heart diseases should be thoroughly reviewed. In pregnant women, especially in the third trimester, the drug should be taken under the supervision of a doctor, as it may affect the delivery process and the health of the fetus.

Diclofenac sodium sustained-release tablets, with gradual and continuous release, have found a special place in the management of chronic and inflammatory pain. The 30-count packages are tailored to different treatment needs, responding to acute and chronic conditions. Adherence to the principles of proper use, avoidance of self-medication, and regular medical supervision are prerequisites for the safe use of this widely used drug.