Nexipharm Capsules

Description

Nexipharm Capsules

Esomeprazole is an oral medication and one of the most widely used drugs in the proton pump inhibitors (PPIs) category, which is recommended and prescribed by a specialist doctor to treat digestive problems related to stomach acid. This drug product, which helps improve the symptoms of digestive diseases by reducing stomach acid production, is offered by Kish Medipharm Pharmaceutical Company under the name Nexipharm. Esomeprazole was first produced under the name Nexium tablets by AstraZeneca Pharmaceutical Company in 2001.

Uses and mechanism of action of Esomeprazole

As mentioned, the drug Esomeprazole is a proton pump inhibitor (PPI) that is, the proton pumps in the stomach cells produce stomach acid. Esomeprazole binds to these pumps, inactivating them and significantly reducing stomach acid secretion. Since Esomeprazole is a therapeutic solution for improving digestive problems, specialists prescribe it to treat and control various conditions. Below are some of the uses of Nexipharm:

• Prevention and treatment of ulcers associated with the use of medications such as nonsteroidal anti-inflammatory drugs
• Treating and improving problems caused by heartburn and indigestion caused by stomach acid
• Gastroesophageal reflux disease (GERD)
• Zollinger-Ellison syndrome
• Reducing the risk of gastrointestinal bleeding in critically ill patients
• Treatment of benign gastric and duodenal ulcers
• Reducing stomach acid before surgery
• Improving esophagitis caused by radiation therapy
• Treatment of Helicobacter pylori infection
• Treatment of stomach and duodenal ulcers
• Barrett's syndrome

Types of Esomeprazole

Esomeprazole is produced in different forms, including oral tablets, oral capsules, powder for oral solution, delayed-release tablets, intravenous injection, Esomeprazole in combination with other drugs and injectable solutions, all over the world, and is known as a strong inhibitor of gastric acid production. It is used as a monotherapy and combination therapy in the treatment of various digestive diseases, as previously announced. This variety in pharmaceutical forms helps the patient to choose the appropriate format in consultation with a specialist physician. Esomeprazole formats are usually available in doses of 20 mg and 40 mg.

Contraindications for Esomeprazole

Although Nexipharm tablets are produced to treat and improve many digestive problems, they are not suitable for everyone. As previously announced, the use of this drug is possible only with a doctor's prescription and by monitoring your condition. If your doctor diagnoses that esomeprazole is not suitable for you, he or she may prescribe an alternative drug. Below, we have briefly mentioned some of the conditions in which people cannot take esomeprazole:

• Hypersensitivity and severe reactions to esomeprazole and its ingredients, other proton pump inhibitors (PPIs) or similar drugs
• History of any severe digestive diseases, such as active bleeding or stomach obstruction
• Long-term use of more than 8 weeks
• Acute or severe liver failure
• Vitamin B12 deficiency
• Pregnancy and breastfeeding
• Children under 1 year old
• Osteoporosis

Drug interactions of Esomeprazole

One of the most important things to consider before taking any medication is drug interactions. Drug problems can cause dangerous side effects. Taking some medications with Nexipharm can pose absorption and metabolic risks. Esomeprazole affects the bioavailability of medications that have pH-dependent absorption by inhibiting gastric acid secretion. The drug interactions of Esomeprazole are summarized below:

• Ampicillin, antifungal agents, clopidogrel, diazepam, and warfarin
• Opioid painkillers: such as morphine, codeine, oxycodone (cause drowsiness and breathing problems)
• Thyroid hormone medications such as levothyroxine (reduces the absorption of thyroid hormone in the body)
• Other proton pump inhibitors (PPIs) such as lansoprazole, pantoprazole, rabeprazole
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (risk of stomach bleeding)
• Antifungal medications, including ketoconazole, itraconazole, and voriconazole
• Antiviral medications including ritonavir, indinavir, and fosamprenavir
• Antihypertensive medications such as captopril, lisinopril, and amlodipine
• Grapefruit and grapefruit juice (increases absorption of esomeprazole)
• Antidepressants (SSRIs) such as citalopram and citalopram
• Ampicillin (reduced antibacterial effectiveness of this drug)
• Birth control pills (risk of increased blood sugar levels)
• Drinking alcohol and its derivatives (hypoglycemia)
• Diego Cousin (increased risk of arrhythmia)

• AIDS treatment drugs
• Clarithromycin
• Clopidogrel
• Saquinavir
• Cilostazol
• Phenytoin

Side effects of Esomeprazole

Although Esomeprazole is considered a safe medication, it can cause side effects due to incorrect dosage, drug interactions, and individual health conditions. The most common side effects of Esomeprazole include:

• Dry mouth
• Yellowing of the skin and eyes
• Liver disorders (increased liver enzymes)
• Increased risk of fractures and osteoporosis
• Musculoskeletal complications
• Salivary gland polyps, asthma, breathing problems and shortness of breath
• Skin problems (rash, itching, redness, swelling, and hives)
• Central nervous system side effects (headache, fatigue, and dizziness)
• Kidney complications (increased risk of kidney infection, impaired kidney function)
• Digestive problems (nausea and vomiting, constipation and diarrhea, abdominal pain)

Important points about Nexipharm

After conducting surveys and conducting field research with customers in pharmacies, we have identified the most common questions and have tried to explain important points about Nexipharm below to prevent confusion about this drug:

• The duration of treatment with Esomeprazole depends on the type of disease and its severity. Nexipharm is usually taken for at least 4 to 8 weeks, but in more severe cases, the treatment period may be longer.
• This medicinal product should be stored in a cool, dry place. Avoid freezing this medicine. Temperatures below 30°C are suitable for storing this medicine.
• All medicinal products should be kept out of the reach of children.
• Nexipharm packages contain 28 tablets and are distributed in blister packs of 14.
• Esomeprazole can cause weight gain.
• Nexipharm does not cause dependence and is not considered a narcotic, but it should be noted that the duration of use of this medication should only be determined by a doctor.

• Long-term use of esomeprazole may cause some side effects, such as decreased absorption of nutrients (such as calcium and magnesium), increased risk of infections, and kidney problems. Your doctor may need to monitor your health regularly to make sure it is safe for you to take the medication.
• Given that the absorption of vitamin B12, calcium, and magnesium decreases while taking esomeprazole, it is best to take nutritional supplements as recommended by your doctor.
• The effectiveness of omeprazole can vary from a few hours to a few days. The best solution is to follow your doctor's instructions and use Nexipharm until the end of the treatment period.
• Since omeprazole is prescribed to treat many digestive problems, different doses are usually recommended. Of course, the dosage will only be determined by a specialist, but in general, GERD is prescribed 20 to 40 mg per day, gastric and duodenal ulcers 40 mg per day for 4 to 8 weeks, and Zollinger-Ellison syndrome 40 to 160 mg per day.
• Esomeprazole will not neutralize stomach acid, so it is not suitable for quick relief of heartburn.
• In many cases, stomach pain is confused with heart pain. Before taking esomeprazole, it is necessary to confirm the cause of the pain with the help of a specialist.
• Usually, the best time to use Nexipharm is half an hour before breakfast.
• Given that side effects of omeprazole can include dizziness and drowsiness, it is best to avoid operating machinery.
• If the expiration date of Esomeprazole has passed, dispose of this product properly after consulting your pharmacist. Please refrain from recommending this product to other people because this medicine has been prescribed only for your current condition.

Conclusion

One of the types of drugs of Kish Medipharm Pharmaceutical Company is omeprazole, which is produced under the trade name Nexipharm capsules in a dose of 40 mg and 14 pieces. This pharmaceutical product is prescribed for the treatment and control of digestive problems and can be considered as monotherapy and combination therapies. One of the most famous names of this drug is Nexium, which was produced by AstraZeneca Company in 2001.

Remember that all the recommendations stated are solely for the purpose of providing more information about the drug and introducing Esomeprazole, and under no circumstances will they take precedence over the instructions of a specialist physician.